| Published Papers |
| No. | Title URL, Journal, Vol( Number), From Page- To Page, Publication date, DOI
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| 3 |
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| 4 | Inflammatory cytokines TNFα, IL-1β, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades. , Science Progress, 104( 4), 1- 21, Oct. 2021, https://doi.org/10.1177/00368504211054985. |
| 5 | A simple immunohistochemical method for detecting microglia in rat brain. , The Gazette of Medical Sciences, 1( 6), 22- 29, Dec. 11, 2020,
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| 6 | HMGB1, a pathogenic molecule that induces neurite degeneration via TLR4-MARCKS, is a potential therapeutic target for Alzheimer's disease. , Scientific reports, 6, 31895- 31895, Aug. 25, 2016, https://doi.org/10.1038/srep31895 |
| 7 | Close association of p38 and JNK with plasminogen-dependent upregulation of PAI-1 in rat astrocytes in vitro. , Neurosci Lett., Vol.471, 66-69.- , Jan. 2010,
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| 8 | Temperature and pressure effect on astrocyte preservation. , Cryobiology and Cryotechnology., Vol.55, 1-7- , Apr. 2009,
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| 9 | Activation of microglia by endotoxin suppresses the secretion of glial cell line-derived neurotrophic factor (GDNF) through the action of protein kinase C alpha (PKC alpha) and mitogen-activated protein kinases (MAPKs) , JOURNAL OF NEUROSCIENCE RESEARCH, 86( 9), 1959- 1971, Jul. 2008, https://doi.org/10.1002/jnr.21657 |
| 10 | Effects of hyperpolarization-activated channel blocker ZD7288 on polar excitations of frog sciatic nerve. , J Physiol Sci, 58, 99-104- , Feb. 2008,
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| 11 | Neuronal regulation by which microglia enhance the production of neurotrophic factors for GABAergic, catecholaminergic, and cholinergic neurons , Neurochem Int, Vol.50, 807-820- , Jul. 2007,
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| 12 | Differential suppression of endotoxin-inducible inflammatory cytokines by nuclear factor kappa B (NFkB) inhibitor in rat microglia. , Neurosci. Lett, Vol. 401, 199-201- , Nov. 2006,
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| 13 | In vitro proliferation of axotomized rat facial nucleus-derived activated microglia in an autocrine fashion , J. Neurosci. Res., Vol. 84, 348-359- , Sep. 2006,
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| 14 | Nonparticipation of nuclear factor kappa B (NFκB) in the signaling cascade of c-Jun N-terminal kinase (JNK)- and p38 mitogen-activated protein kinase (p38MAPK)-dependent tumor necrosis factor alpha (TNFα) induction in lipopolysaccharide (LPS)-stimulated microglia , Brain Research, 1073-1074( 1), 48- 59, Feb. 16, 2006, https://doi.org/10.1016/j.brainres.2005.12.043 |
| 15 | Enhancement of urokinase-type plasminogen activator (uPA) secretion, but not that of substrate plasminogen (PGn), by rat microglia stimulated with neuronal conditioned medium , Neuroscience Letters, 378( 1), 13- 17, Apr. 11, 2005, https://doi.org/10.1016/j.neulet.2004.12.006 |
| 16 | Microglia: resident immune-related cells in the central nervous system. , Recent Res. Devl. Infection & Immunity,, Vol.378, 11-23- , Feb. 2005,
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| 17 |
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| 18 | Ceramide activates microglia to enhance the production/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro , Journal of Neurochemistry, 80( 4), 697- 705, 2002, https://doi.org/10.1046/j.0022-3042.2001.00752.x |
| 19 | Neurotrophin secretion from cultured microglia , JOURNAL OF NEUROSCIENCE RESEARCH, 65( 4), 322- 331, Aug. 2001,
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| 20 | Intact microglia are cultured and non-invasively harvested without pathological activation using a novel cultured cell recovery method , BIOMATERIALS, 22( 11), 1213- 1223, Jun. 2001,
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| 21 |
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| 22 |
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| 23 | MODULATORY EFFECT OF PLASMINOGEN ON NMDA-INDUCED INCREASE IN INTRACELLULAR FREE CALCIUM-CONCENTRATION IN RAT CULTURED HIPPOCAMPAL-NEURONS , NEUROSCIENCE LETTERS, 179( 1-2), 87- 90, Sep. 1994,
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| 24 |
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| 25 |
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| 26 | PRODUCTION OF BASIC FIBROBLAST GROWTH-FACTOR IN CULTURED RAT-BRAIN MICROGLIA , NEUROSCIENCE LETTERS, 123( 2), 229- 231, Feb. 1991,
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| Conference Activities & Talks |
| No. | Title, Conference, Publication date, Promoter, Venue
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| 1 | Changes of mitogen-activated protein kinases (MAPKs) in the axotomized rat facial nucleus., , Nov. 9, 2022, ,
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| 2 | Changes of c-Jun/c-Fos and CREB/ATF2 proteins after rat facial nerve axotomy., , Jul. 1, 2022, ,
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| 3 | Involvement of NFkB in the induction of inflammatory cytokines in microglia., , Jul. 1, 2022, ,
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| 4 | Responses of several GABAA receptors to facial nerve injury in rat, , Jul. 30, 2021, ,
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| 5 | Inflammatory cytokines TNF, IL-1, and IL-6 are induced in endotoxin- stimulated microglia through different signaling cascades, , Jul. 29, 2021, ,
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| 6 | Role of p38 on microglial activation/proliferation in axotomized rat facial nucleus, , Sep. 14, 2020, ,
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| 7 | Early response of motoneurons in axotomized rat facial nucleus, , Jul. 31, 2020, ,
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| 8 | Induction of tumor necrosis factor alpha (TNF) expression in microglia by the accumulation of a superoxide anion donor in rat cerebral cortex, , Jul. 30, 2020, ,
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| 9 | Involvement of superoxide anion in the induction of TNFα in microglia., 40th Annual Meeting of Society for Neuroscience, Nov. 2011, ,
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| 10 | Involvement of superoxide anion in the induction of TNFα in microglia., 40th Annual Meeting of Society for Neuroscience, 2011, ,
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| 11 | Cholinergic neurons in rat facial nucleus, The 53rd Annual Meeting of the Japanese Society for Neurochemistry, 33rd Annual Meeting of the Japan Neuroscience Society, Sep. 2010, ,
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| 12 | Production of anti-inflammatory cytokines in microglia, The 53rd Annual Meeting of the Japanese Society for Neurochemistry, 33rd Annual Meeting of the Japan Neuroscience Society, Sep. 2010, ,
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| 13 | Superoxide anion as an essential inducer of TNFa in microglia, The 53rd Annual Meeting of the Japanese Society for Neurochemistry, 33rd Annual Meeting of the Japan Neuroscience Society, Sep. 2010, ,
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| 14 | Characteristic response of astrocytes to plasminogen to upregulate transforming growth factor beta 3 (TGFb3) ptroduction/secretion through the action of phosphatidylinositol 3-kinase (PI3K)-Akt/PKB signaling cascade., 9th European Meeting on Glial Cells in Health and Disease,, Sep. 2009, ,
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| 15 | Association of mitogen-activated protein kinase with upregulation of PAI-1 in rat astrocytes stimulated with plasminogen, The 32nd Annual Meeting of the Japan Neuroscience Society, Sep. 2009, ,
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| 16 | Microglia activated by endotoxin suppress the secretion of glial cell line-derived neurotrophic factor (GDNF)., 38th Annual Meeting of Society for Neuroscience, Nov. 2008, ,
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| 17 | Upregulation of microglial mitogen macrophage-colony stimulating factor (M-CSF) and the receptor cFms in rat axotomized facial nucleus, The 51th Annual Meeting of the Japan Neurochemical Society, Sep. 2008, ,
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| 18 | Neuronal stimulation leading to upregulation of glutamate transporter-1 (GLT-1) in rat microglia in vitro., The 31th Annual Meeting of the Japan Neuroscience Society, Jul. 2008, ,
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| 19 | Neuronal stimulation changes microglia to more neurotrophic cells., The 21st Meeting of International Society for Neurochemistry, Aug. 2007, ,
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| 20 | Characterization of axotomized rat facial nucleus-derived activated microglia in vitro., 36th Annual Meeting of Society for Neuroscience, Oct. 2006, ,
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| Research Grants & Projects |
| No. | Offer organization, System name, Title, Fund classification, Date
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| 1 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Study on the molecular mechanism by which microglia transform into phagocytes, , 2003 - 2005
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| 2 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, A Role of Nitric Oxide in the Disease Course of Experimental Retroviral Encephalopaty, , 2000 - 2002
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| 3 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Study of the molecular mechanism by which microglia are activated in the brain, , 1998 - 2000
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| 4 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Regulation of synapse by microglia, , 1998 - 2001
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| 5 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Significance of microglia derived plasmin-generating proteases in the nervous system, , 1995 - 1996
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| 6 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Fundamental study concerning the physiological function of microglia in the brain, , 1993 - 1994
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| 7 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Transfection of Tyrosine Hydroxylase cDNA into Cultured Cells : application for Intracerebral Grafting., , 1989 - 1990
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| 8 | Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Action mechanisms of antiepileptic drugs in relation to cellular lipids, , 1985 - 1988
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