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ANGATA Kiyohiko

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Published Papers
No.Title URL, Journal, Vol( Number), From Page- To Page, Publication date, DOI 
1
Chondroitin sulfate modification of CSPG4 regulates the maintenance and differentiation of glioma-initiating cells via integrin-associated signaling. , The Journal of biological chemistry, 300( 3), 105706- 105706, Mar. 2024, https://doi.org/10.1016/j.jbc.2024.105706 
2
Single-cell Glycogenomics Deciphers Links Between Altered Transcriptional Regulation and Aberrant Glycosylation in Alzheimer's Disease. , bioRxiv : the preprint server for biology, ,   , Dec. 27, 2023, https://doi.org/10.1101/2023.12.25.573290 
3
Serum O-glycosylated hepatitis B surface antigen levels in patients with chronic hepatitis B during nucleos(t)ide analog therapy. , BMC gastroenterology, 22( 1), 270- 270, May. 31, 2022, https://doi.org/10.1186/s12876-022-02352-4 
4
O-glycosylated HBsAg peptide can induce specific antibody neutralizing HBV infection. , Biochimica et biophysica acta. General subjects, 1866( 1), 130020- 130020, Jan. 2022, https://doi.org/10.1016/j.bbagen.2021.130020 
5
Association between the expression of core 3 synthase and survival outcomes of patients with cholangiocarcinoma. , Oncology letters, 22( 5), 760- 760, Nov. 2021, https://doi.org/10.3892/ol.2021.13021 
6
LM-GlycomeAtlas Ver. 2.0: An Integrated Visualization for Lectin Microarray-based Mouse Tissue Glycome Mapping Data with Lectin Histochemistry. , Journal of proteome research, 20( 4), 2069- 2075, Apr. 2, 2021, https://doi.org/10.1021/acs.jproteome.0c00907 
7
Enzyme assay of β1,3-N-acetylgalactosaminyltransferase 2 (B3GALNT2) , , ,   , 2021,  
8
Multi-serum glycobiomarkers improves the diagnosis and prognostic prediction of cholangiocarcinoma. , Clinica chimica acta; international journal of clinical chemistry, 510,  142- 149, Nov. 2020, https://doi.org/10.1016/j.cca.2020.07.017 
9
Screening siRNAs against host glycosylation pathways to develop novel antiviral agents against hepatitis B virus. , Hepatology research : the official journal of the Japan Society of Hepatology, 50( 10), 1128- 1140, Oct. 2020, https://doi.org/10.1111/hepr.13552 
10
The GlyCosmos Portal: a unified and comprehensive web resource for the glycosciences. , Nature methods, 17( 7), 649- 650, Jul. 2020, https://doi.org/10.1038/s41592-020-0879-8 
11
Clinicopathological significance of core 3 O-glycan synthetic enzyme, β1,3-N-acetylglucosaminyltransferase 6 in pancreatic ductal adenocarcinoma. , PloS one, 15( 11), e0242851- , 2020, https://doi.org/10.1371/journal.pone.0242851 
12
Glycogene Expression Profiling of Hepatic Cells by RNA-Seq Analysis for Glyco-Biomarker Identification. , Frontiers in oncology, 10,  1224- 1224, 2020, https://doi.org/10.3389/fonc.2020.01224 
13
LM-GlycomeAtlas Ver. 1.0: A Novel Visualization Tool for Lectin Microarray-Based Glycomic Profiles of Mouse Tissue Sections. , Molecules (Basel, Switzerland), 24( 16),  , Aug. 15, 2019, https://doi.org/10.3390/molecules24162962 
14
Identification of mammalian glycoproteins with type-I LacdiNAc structures synthesized by the glycosyltransferase B3GALNT2. , The Journal of biological chemistry, 294( 18), 7433- 7444, May. 3, 2019, https://doi.org/10.1074/jbc.RA118.006892 
15
The GlyCosmos Web Portal: glycan structures, glycogenes, glycoproteins, pathways, diseases and more! , GLYCOBIOLOGY, 28( 12), 1070- 1071, Dec. 2018,  
16
Highly Sensitive Glycan Profiling of Hepatitis B Viral Particles and a Simple Method for Dane Particle Enrichment. , Analytical chemistry, 90( 17), 10196- 10203, Sep. 4, 2018, https://doi.org/10.1021/acs.analchem.8b01030 
17
Enhancement of Human Sperm Motility by Novel Recombinant Endo-beta-Galactosidases , Reproductive Sciences, 24,   , 2017,  
18
Cloning of endo-beta-galactosidase from B. fragilis , Glycobiology, 25( 11),  , 2015,  
19
ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 (ST8SIA4) , Handbook of Glycosyltransferases and Related Genes, Second Edition, 2,  805- 812, Jan. 1, 2014, https://doi.org/10.1007/978-4-431-54240-7_28 
20
Beta1,3-NAcetylgalactosaminyltransferase 2 (B3GALNT2) , Handbook of Glycosyltransferases and Related Genes, Second Edition, 1,  439- 445, Jan. 1, 2014, https://doi.org/10.1007/978-4-431-54240-7_165 
21
ST3 beta-galactoside alpha-2,3-sialyltransferase 1 (ST3GAL1) , Handbook of Glycosyltransferases and Related Genes, Second Edition, 2,  637- 644, Jan. 1, 2014, https://doi.org/10.1007/978-4-431-54240-7_27 
22
In vivo regulation of steroid hormones by the Chst10 sulfotransferase in mouse. , The Journal of biological chemistry, 288( 7), 5007- 16, Feb. 15, 2013, https://doi.org/10.1074/jbc.M112.433474 
23
Fer kinase regulates cell migration through α-dystroglycan glycosylation. , Molecular biology of the cell, 23( 5), 771- 80, Mar. 2012, https://doi.org/10.1091/mbc.E11-06-0517 
24
Fer kinase regulates prostate cancer cell migration through alpha-dystroglycan glycosylation , European Urology Supplements, 11( 1),  , 2012,  
25
FER KINASE REGULATES PROSTATE CANCER CELL MIGRATION THROUGH alpha-DYSTROGLYCAN GLYCOSYLATION , Journal of Urology, 187( 4),  , 2012, https://doi.org/10.1016/j.juro.2012.02.551 
26
HNK-1 glycan functions as a tumor suppressor for astrocytic tumor. , The Journal of biological chemistry, 286( 37), 32824- 33, Sep. 16, 2011, https://doi.org/10.1074/jbc.M111.245886 
27
Novel Function of HNK-1 Sulfotransferase as a Hormone Regulator , Glycobiology, 21( 11), 1516- 1516, 2011,  
28
Downregulation of Fer Tyrosine Kinase Signaling Increases a-dystroglycan-mediated Cell Adhesion Thereby Suppresses Tumor Formation , Glycobiology, 21( 11),  , 2011,  
29
HNK-1 Glycan Functions as a Tumor Suppressor for Astrocytic Tumor , Glycobiology, 21( 11), 1530- 1530, 2011,  
30
Roles of polysialic acid in migration and differentiation of neural stem cells. , Methods in enzymology, 479( C), 25- 36, 2010, https://doi.org/10.1016/S0076-6879(10)79002-9 
31
Amino Acid Residues Required for ST8SiaIV to Recognize NCAM and CMP-Sialic Acid , Glycobiology, 20( 11), 1476- 1476, 2010,  
32
Carbohydrates of neural cell glycoproteins: Structure, biosynthesis, and function , Neuroglycobiology: (Molecular and Cellular Neurobiology), ,   , Sep. 1, 2009, https://doi.org/10.1093/acprof:oso/9780198525387.003.0001 
33
Tumor suppressor function of laminin-binding alpha-dystroglycan requires a distinct beta3-N-acetylglucosaminyltransferase. , Proceedings of the National Academy of Sciences of the United States of America, 106( 29), 12109- 14, Jul. 21, 2009, https://doi.org/10.1073/pnas.0904515106 
34
Regulating Specific Extracellular Signaling in Neural Cells by Polysialic Acid and HNK-1 , Glycobiology, 19( 11), 1366- 1366, 2009,  
35
HNK-1 Glycan Expression is Reversely Correlated with Invasion of Glioma, Acting as a Tumor Suppressor , Glycobiology, 19( 11), 1365- 1365, 2009,  
36
CMP substitutions preferentially inhibit polysialic acid synthesis. , Glycobiology, 18( 2), 187- 94, Feb. 2008, https://doi.org/10.1093/glycob/cwm132 
37
HNK-1 Sulfotransferase is Regulating Steroid Hormone Activity , Glycobiology, 18( 11), 977- 977, 2008,  
38
Alteration of Neural Cell Specific Carbohydrates, Polysialic Acid and HNK-1 Glycan, to Regulate Roles of Neural Cells , Glycobiology, 18( 11), 980- 980, 2008,  
39
Laminin-Binding Glycans Attached to alpha-Dystroglycan Function as a Novel Tumor Suppressor , Glycobiology, 18( 11), 940- 940, 2008,  
40
Polysialic acid-directed migration and differentiation of neural precursors are essential for mouse brain development. , Molecular and cellular biology, 27( 19), 6659- 68, Oct. 2007, https://doi.org/10.1128/MCB.00205-07 
41
Polysialic acid determines cell fate of neural precursor cells in mouse brain development , Glycobiology, 16( 11), 1148- 1148, 2006,  
42
Cellular and molecular analysis of neural development of glycosyltransferase gene knockout mice. , Methods in enzymology, 417,  25- 37, 2006, https://doi.org/10.1016/S0076-6879(06)17003-2 
43
Polysialic acid facilitates tumor invasion by glioma cells. , Glycobiology, 15( 9), 887- 94, Sep. 2005, https://doi.org/10.1093/glycob/cwi071 
44
Polysialic acid is required for coordinated migration of neural precursor cells during brain development , Glycobiology, 15( 11), 1225- 1225, 2005,  
45
Abnormal neural development in ST8Sia II and ST8Sia IV double knockout mice lacking polysialic acid , Faseb Journal, 19( 4),  , 2005,  
46
Sialyltransferase ST8Sia-II assembles a subset of polysialic acid that directs hippocampal axonal targeting and promotes fear behavior. , The Journal of biological chemistry, 279( 31), 32603- 13, Jul. 30, 2004, https://doi.org/10.1074/jbc.M403429200 
47
Molecular dissection of the ST8Sia IV polysialyltransferase. Distinct domains are required for neural cell adhesion molecule recognition and polysialylation. , The Journal of biological chemistry, 279( 24), 25883- 90, Jun. 11, 2004, https://doi.org/10.1074/jbc.M401562200 
48
Absence of polysialic acid affect neural development in ST8Sia II and ST8Sia IV double knockout mice , Glycobiology, 14( 11), 1142- 1142, 2004,  
49
Polysialic acid and mucin type o-glycans on the neural cell adhesion molecule differentially regulate myoblast fusion. , The Journal of biological chemistry, 278( 49), 49459- 68, Dec. 5, 2003, https://doi.org/10.1074/jbc.M308316200 
50
Different glycosyltransferases are differentially processed for secretion, dimerization, and autoglycosylation. , Glycobiology, 13( 12), 941- 53, Dec. 2003, https://doi.org/10.1093/glycob/cwg117 
51
Polysialyltransferases: major players in polysialic acid synthesis on the neural cell adhesion molecule. , Biochimie, 85( 1-2), 195- 206, 2003, https://doi.org/10.1016/S0300-9084(03)00051-8 
52
Molecular dissection of a polysialyltransferase, ST8Sia IV: Domains distinctively required for NCAM recognition and polysialylation , Glycobiology, 13( 11), 902- 902, 2003,  
53
ST8Sia II and ST8Sia IV polysialyltransferases exhibit marked differences in utilizing various acceptors containing oligosialic acid and short polysialic acid. The basis for cooperative polysialylation by two enzymes. , The Journal of biological chemistry, 277( 39), 36808- 17, Sep. 27, 2002, https://doi.org/10.1074/jbc.M204632200 
54
Biosynthesis of HNK-1 glycans on O-linked oligosaccharides attached to the neural cell adhesion molecule (NCAM): the requirement for core 2 beta 1,6-N-acetylglucosaminyltransferase and the muscle-specific domain in NCAM. , The Journal of biological chemistry, 277( 20), 18182- 90, May. 17, 2002, https://doi.org/10.1074/jbc.M201312200 
55
A small-molecule modulator of poly-alpha 2,8-sialic acid expression on cultured neurons and tumor cells. , Science (New York, N.Y.), 294( 5541), 380- 1, Oct. 12, 2001, https://doi.org/10.1126/science.1062192 
56
Molecular cloning and expression of a novel human beta-Gal-3-O-sulfotransferase that acts preferentially on N-acetyllactosamine in N- and O-glycans. , The Journal of biological chemistry, 276( 26), 24388- 95, Jun. 29, 2001, https://doi.org/10.1074/jbc.M103135200 
57
Unique disulfide bond structures found in ST8Sia IV polysialyltransferase are required for its activity. , The Journal of biological chemistry, 276( 18), 15369- 77, May. 4, 2001, https://doi.org/10.1074/jbc.M100576200 
58
Polysialyltransferase ST8Sia II (STX) polysialylates all of the major isoforms of NCAM and facilitates neurite outgrowth. , Glycobiology, 11( 3), 231- 9, Mar. 2001, https://doi.org/10.1093/glycob/11.3.231 
59
Two unique oligosaccharide modifications of NCAM: polysialic acid and Gal beta 1-3GalNAc-Thr on the MSD motif regulate myoblast fusion , Glycobiology, 11( 10),  , 2001,  
60
Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III. , The Journal of biological chemistry, 275( 24), 18594- 601, Jun. 16, 2000, https://doi.org/10.1074/jbc.M910204199 
61
The mitochondrial DNA of Dictyostelium discoideum: complete sequence, gene content and genome organization. , Molecular & general genetics : MGG, 263( 3), 514- 9, Apr. 2000, https://doi.org/10.1007/PL00008685 
62
Polysialic acid attached to O-linked oligosaccharides in NCAM: Biosynthesis and function , Glycobiology, 10( 10),  , 2000,  
63
Elevated expression of free deaminoneuraminic acid in mammalian cells cultured in mannose-rich media. , Biochemical and biophysical research communications, 261( 2), 326- 31, Aug. 2, 1999,  
64
Differential and cooperative polysialylation of the neural cell adhesion molecule by two polysialyltransferases, PST and STX. , The Journal of biological chemistry, 273( 43), 28524- 32, Oct. 23, 1998, https://doi.org/10.1074/jbc.273.43.28524 
65
Polysialic acid, a unique glycan that is developmentally regulated by two polysialyltransferases, PST and STX, in the central nervous system: from biosynthesis to function. , Pathology international, 48( 9), 665- 77, Sep. 1998, https://doi.org/10.1111/j.1440-1827.1998.tb03967.x 
66
Molecular cloning and expression of GDP-D-mannose-4,6-dehydratase, a key enzyme for fucose metabolism defective in Lec13 cells. , The Journal of biological chemistry, 273( 23), 14582- 7, Jun. 5, 1998, https://doi.org/10.1074/jbc.273.23.14582 
67
Developmental regulation of polysialic acid synthesis in mouse directed by two polysialyltransferases, PST and STX. , Glycobiology, 8( 4), 415- 24, Apr. 1998, https://doi.org/10.1093/glycob/8.4.415 
68
Molecular cloning and expression of a novel human trans-Golgi network glycoprotein, TGN51, that contains multiple tyrosine-containing motifs. , The Journal of biological chemistry, 273( 2), 981- 8, Jan. 9, 1998, https://doi.org/10.1074/jbc.273.2.981 
69
Differential and cooperative polysialylation of NCAM by two polysialyltransferases, PST and STX , Glycobiology, 8( 11),  , 1998,  
70
Expression cloning of cDNA encoding a human beta-1,3-N-acetylglucosaminyltransferase that is essential for poly-N-acetyllactosamine synthesis. , Proceedings of the National Academy of Sciences of the United States of America, 94( 26), 14294- 9, Dec. 23, 1997, https://doi.org/10.1073/pnas.94.26.14294 
71
A site-specific DNA endonuclease specified by one of two ORFs encoded by a group I intron in Dictyostelium discoideum mitochondrial DNA. , Gene, 191( 1), 115- 21, May. 20, 1997, https://doi.org/10.1016/S0378-1119(97)00050-4 
72
Human STX polysialyltransferase forms the embryonic form of the neural cell adhesion molecule. Tissue-specific expression, neurite outgrowth, and chromosomal localization in comparison with another polysialyltransferase, PST. , The Journal of biological chemistry, 272( 11), 7182- 90, Mar. 14, 1997, https://doi.org/10.1074/jbc.272.11.7182 
73
Group-I introns in the cytochrome c oxidase genes of Dictyostelium discoideum: two related ORFs in one loop of a group-I intron, a cox1/2 hybrid gene and an unusually large cox3 gene. , Current genetics, 31( 1), 80- 8, Jan. 1997, https://doi.org/10.1007/s002940050179 
74
Molecular cloning and expression of human trans-Golgi network 46, 48 and 51 glycoproteins that contain unique extracellular domain , Glycobiology, 7( 7), 131- 131, 1997,  
75
Requirement for polysialic acid synthesis in N-CAM , Glycobiology, 7( 7), 89- 89, 1997,  
76
Analysis of a tRNA gene-like sequence (t-element) with TTA at the anticodon position in the mitochondrial DNA of Dictyostelium discoideum , Journal of Plant Research, 109( 1), 1- 6, Mar. 1996, https://doi.org/10.1007/bf02344281 
77
Molecular cloning and expression of human trans-Golgi network 38 glycoprotein that contains unique extracellular sequence , Molecular Biology of the Cell, 7,  2565- 2565, 1996,  
78
Developmentally regulated expression of polysialic acid in the central nervous system directed by two polysialyltransferases, PST and STX , Molecular Biology of the Cell, 7,  738- 738, 1996,  
79
A group-I intron in the mitochondrial large-subunit ribosomal RNA-encoding gene of Dictyostelium discoideum: same site localization in alga and in vitro self-splicing. , Gene, 153( 1), 49- 55, Feb. 3, 1995, https://doi.org/10.1016/0378-1119(94)00732-8 
80
Codon usage, genetic code and phylogeny of Dictyostelium discoideum mitochondrial DNA as deduced from a 7.3-kb region. , Current genetics, 27( 3), 249- 56, Feb. 1995, https://doi.org/10.1007/BF00326157 
81
DEVELOPMENT OF A THIN-FILM OXYGEN SENSOR FOR COMBUSTION CONTROL OF GAS APPLIANCES , Sensors and Actuators B-Chemical, 14( 1-3),  , 1993, https://doi.org/10.1016/0925-4005(93)85148-4 
82
ORF209 of Dictyostelium discoideum mitochondrial DNA has a homologue in chloroplast DNA. , Plant molecular biology, 15( 4), 659- 60, Oct. 1990, https://doi.org/10.1007/BF00017840 

 

MISC
No.Title URL, Journal, Vol( Number), From Page- To Page, Publication date 
1
The expression of core 3 synthase is correlated with survival outcomes of patients with cholangiocarcinoma , 日本糖質学会年会要旨集, 41st,   , 2022 
2
Glycoscience portal GlyCosmos 2021 , 日本糖質学会年会要旨集, 40th,   , 2021 
3
Glycan-related omics data integrated in the GlyCosmos Glycoscience Portal , 日本分子生物学会年会プログラム・要旨集(Web), 44th,   , 2021 
4
The GlyCosmos portal as a partner in the GlySpace Alliance to provide access to integrated glycan-related data resources , GLYCOBIOLOGY, 30( 12), 1023- 1023, Dec. 2020 
5
Clinicopathological impact of O-glycans on pancreatic ductal adenocarcinoma , 日本病理学会会誌, 109( 1),  , 2020 
6
Application of lectin microarray-based glycan profiling targeting extracellular and virus particles , Abstracts for Annual Meeting of Japanese Proteomics Society, 2016,  86- 86, 2016 
7
Identification of glycoproteins bearing core 3-glycans , 日本プロテオーム学会大会プログラム・抄録集, 2014 (Web),  80- 80, 2014 
8
Large-scale identification of glycoproteins having specific glycans for mechanism elucidation in protein-specific glycosylation , 日本プロテオーム学会大会プログラム・抄録集, 2014 (Web),  25- 25, 2014 
9
Group I introns and ORFs encoded within the introns in mitochondrial LSU rRNA gene of cellular slime molds. , 日本分子生物学会年会プログラム・講演要旨集, 17th,   , 1994 
10
Group I introns in the cytochrome oxidase gene of Dictyostelium discoideum. , 日本分子生物学会年会プログラム・講演要旨集, 17th,   , 1994 
11
Analysis of small molecular RNA (5S) found in Dictyostelium discoideum mitochondria. , 日本分子生物学会年会プログラム・講演要旨集, 17th,   , 1994 

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Construction of Glycobiomarker Deevelopment Technology Driven by Glycoinformatics, ,  Apr. 2023 - Mar. 2026 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Elucidation of biological function of glycan by integrated omics analysis based on glycoproteome., ,  Apr. 2015 - Mar. 2018 
3
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, N-glycosylated glycoproteome analysis of glycosyltransferase-modified mice for comprehensive understanding of glycan functions, ,  Apr. 2012 - Mar. 2015 

 

Participation in Research Projects
No.Name of Project, Date of Participating 
1
,  Apr. 2023 - Mar. 2024 
2
,  Apr. 2023 - Mar. 2024 
3
,  Apr. 2023 - Mar. 2024