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MARUTA Shinsaku

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Published Papers
No.Title URL, Journal, Vol( Number), From Page- To Page, Publication date, DOI 
1
Control of small GTPase Ras using a calmodulin-based ionochromic nanodevice , Biosciences, Biotechnology Research Asia, ,   , Jun. 2024,  
2
Photocontrol of small GTPase Ras fused with a photoresponsive protein , Journal of Biochemistry, ,   , Feb. 2024, https://doi.org/10.1093/jb/mvae017 
3
Multimerization of small G-protein H-Ras induced by chemical modification at hyper variable region with caged compound , The Journal of Biochemistry, 171( 2), 215- 225, Feb. 21, 2022, https://doi.org/10.1093/jb/mvab120 
4
Photocontrol of GTPase Cycle and Multimerization of the Small G-Protein H-Ras using Photochromic Azobenzene Derivatives , Biosciences Biotechnology Research Asia, 18( 4), 661- 672, Dec. 30, 2021, https://doi.org/10.13005/bbra/2949 
5
Kolaflavanone, a biflavonoid derived from medicinal plant Garcinia, is an inhibitor of mitotic kinesin Eg5 , The Journal of Biochemistry, 170( 5), 611- 622, Dec. 28, 2021, https://doi.org/10.1093/jb/mvab083 
6
Novel photochromic inhibitor for mitotic kinesin Eg5 which forms multiple isomerization states , The Journal of Biochemistry, 170,  229- 237, Aug. 2021,  
7
Time-resolved detection of SDS-induced conformational changes in alpha-synuclein by a micro-stopped-flow system , RSC ADVANCES, 11( 2), 1086- 1097, Jan. 2021, https://doi.org/10.1039/d0ra09614h 
8
Time-resolved detection of SDS-induced conformational changes in α-synuclein by a micro-stopped-flow system. , RSC advances, 11( 2), 1086- 1097, Dec. 24, 2020, https://doi.org/10.1039/d0ra09614h 
9
Spiropyran labeling for sensitive probing of protein diffusion by the transient grating method , Chemical Physics Letters, 739,  136919- , Jan. 2020, https://doi.org/10.1016/j.cplett.2019.136919 
10
Morelloflavone as a novel inhibitor of mitotic kinesin Eg5 , The Journal of Biochemistry, 166,  129- 137, Aug. 2019,  
11
Highly efficient photocontrol of mitotic kinesin Eg5 ATPase activity using a novel photochromic compound composed of two azobenzene derivatives , The Journal of Biochemistry, 164,  295-301- , May. 2018,  
12
Photo-control of the mitotic kinesin Eg5 using a novel photochromic inhibitor composed of a spiropyran derivative , The Journal of Biochemistry, 164,  239-246- , Apr. 2018,  
13
Interaction of a novel fluorescent GTP analogue with the small G-protein K-Ras. , Journal of biochemistry, 159( 1), 41- 8, Jan. 2016, https://doi.org/10.1093/jb/mvv071 
14
Photocontrol of the mitotic kinesin Eg5 using a novel S-trityl-l-cysteine analogue as a photochromic inhibitor , JOURNAL OF BIOCHEMISTRY, 155( 4), 257- 263, Apr. 2014, https://doi.org/10.1093/jb/mvu004 
15
Nucleotide-dependent displacement and dynamics of the alpha-1 helix in kinesin revealed by site-directed spin labeling EPR , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 443( 3), 911- 916, Jan. 2014, https://doi.org/10.1016/j.bbrc.2013.12.063 
16
2P172 Nucleotide-dependent Displacement and Dynamics of α-1 Helix in Motor Protein Kinesin As Revealed by Site Directed Spin Labeling ESR(11. Molecular motor,Poster) , Seibutsu Butsuri, 53( 1), S187- , 2013, https://doi.org/10.2142/biophys.53.S187_4 
17
2P174 Photo regulted inhibitor composed of photochromic molecules for mitotic kinesin Eg5(11. Molecular motor,Poster) , Seibutsu Butsuri, 53( 1), S187- , 2013, https://doi.org/10.2142/biophys.53.S187_6 
18
2P175 Incorporation of photochromic molecule into the functional loop L5 of mitotic kinesin Eg5 and its photo regulation(11. Molecular motor,Poster) , Seibutsu Butsuri, 53( 1), S188- , 2013, https://doi.org/10.2142/biophys.53.S188_1 
19
1PS038 Structural dynamics of necklinker docking, interlinker strain and nucleotide-to-linker transmission in kinesin probed by spin-label ESR(The 50th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 52,  S80- , 2012, https://doi.org/10.2142/biophys.52.S80_5 
20
Biochemical characterization of the novel rice kinesin K23 and its kinetic study using fluorescence resonance energy transfer between an intrinsic tryptophan residue and a fluorescent ATP analogue , Journal of Biochemistry, 149( 5), 539- 550, May. 2011, https://doi.org/10.1093/jb/mvr012 
21
Characterization of a novel rice kinesin O12 with a calponin homology domain. , Journal of biochemistry, 149( 1), 91- 101, Jan. 2011, https://doi.org/10.1093/jb/mvq122 
22
3M1346 Characterization of photochromic ATP analogue as a substrate for myosin(Molecular motor5,The 49th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 51,  S152- S153, 2011, https://doi.org/10.2142/biophys.51.S152_6 
23
1M1324 Structural Dynamics of Mutant Kinesin with Lengthened Neck Linker by Distance Measurements Using Spin-labeling EPR(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 51,  S63- , 2011, https://doi.org/10.2142/biophys.51.S63_3 
24
1M1436 Kinetic characterization of the Rice Plant Kinesins using Fluorescent-ATP Analogue(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 51,  S64- , 2011, https://doi.org/10.2142/biophys.51.S64_2 
25
1M1412 Photo-regulation of kinesin in which functional loop L5 was modified by photochromic molecule(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 51,  S63- S64, 2011, https://doi.org/10.2142/biophys.51.S63_6 
26
1M1336 Conformational change of alfa-1 helix of kinesin detected by electron paramagnetic resonance (EPR)(Molecular motor 2,The 49th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 51,  S63- , 2011, https://doi.org/10.2142/biophys.51.S63_4 
27
Crystallographic analysis reveals a unique conformation of the ADP-bound novel rice kinesin K16. , Biochemical and biophysical research communications, 401( 2), 251- 6, Oct. 15, 2010, https://doi.org/10.1016/j.bbrc.2010.09.043 
28
2P182 Preparation of microtubules derived from plant and its interaction with rice plant kinesin(The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S114- , 2010, https://doi.org/10.2142/biophys.50.S114_4 
29
2P188 Photo-regulation of kinesin ATPase using microtubules modified with photochromic molecule(The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S115- , 2010, https://doi.org/10.2142/biophys.50.S115_4 
30
2P181 Kinetic studies on the novel rice kinesin K23 utilizing FRET between the intrinsic tryptophan residue and fluorescent ATP analogue(The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S114- , 2010, https://doi.org/10.2142/biophys.50.S114_3 
31
2P172 Conformational change of α1 helix of kinesin(The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S112- , 2010, https://doi.org/10.2142/biophys.50.S112_5 
32
2P187 Control of kinesin ATPase activity by modification of functional loop L5(The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S115- , 2010, https://doi.org/10.2142/biophys.50.S115_3 
33
1P176 Interaction of novel fluorescent non-nucleotide ATP analogue with ATP-driven molecular motors(Molecular motor,The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S50- , 2010, https://doi.org/10.2142/biophys.50.S50_3 
34
1P198 Ca^<2+> dependent dimerization of kinesin-CaM and Kinesin M13 fusion proteins(Molecular motor,The 48th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 50( 2), S54- , 2010, https://doi.org/10.2142/biophys.50.S54_2 
35
Photocontrol of Calmodulin Interaction with Target Peptides using Azobenzene Derivative , JOURNAL OF BIOCHEMISTRY, 146( 4), 581- 590, Oct. 2009, https://doi.org/10.1093/jb/mvp107 
36
2P-117 Analysis of conformational change of kinesin neck-linker using using small angle X-ray solution scattering(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S124- , 2009, https://doi.org/10.2142/biophys.49.S124_5 
37
2P-111 Interaction of the novel rice kineisn O12 that has the calponin homology domain with actin(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S123- , 2009, https://doi.org/10.2142/biophys.49.S123_4 
38
1P-271 Kinesin Calmodulin Fusion Protein as a Molecular Shuttle(Bioengineering, The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S105- , 2009, https://doi.org/10.2142/biophys.49.S105_2 
39
2P-114 Photo-regulation of kinesin function using azobenzene derivative(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S124- , 2009, https://doi.org/10.2142/biophys.49.S124_2 
40
2P-115 The functional role of the unique loop L5 of kinesin(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S124- , 2009, https://doi.org/10.2142/biophys.49.S124_3 
41
2P-116 Synthesis of novel fluorescent ATP analogue and interaction with nucleotide dependent motor proteins(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S124- , 2009, https://doi.org/10.2142/biophys.49.S124_4 
42
2P-112 Characterization of the novel rice kinesin K23(Molecular motor,The 47th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 49,  S123- S124, 2009, https://doi.org/10.2142/biophys.49.S123_5 
43
3P-149 Study of the dynamic structure of kinesin by site-directed spin labeling ESR (electron spin resonance)(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S150- , 2008, https://doi.org/10.2142/biophys.48.S150_5 
44
3P-157 Photo-regulation of kinesin using photo-responsible caged compound(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S151- , 2008, https://doi.org/10.2142/biophys.48.S151_6 
45
3P-145 Photo-Control of Calmodulin Target protein using Photochromic Compound(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S150- , 2008, https://doi.org/10.2142/biophys.48.S150_1 
46
3P-159 Photo-regulation of kinesin ATPase activity using photochromic molecule(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S152- , 2008, https://doi.org/10.2142/biophys.48.S152_1 
47
2P-178 Preparation and Characterization of Novel Rice Kinesin E15(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S102- , 2008, https://doi.org/10.2142/biophys.48.S102_5 
48
2P-170 Kinetic characterization of the novel rice kineisn L05 and D04 using fluorescent ATP analogue(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S101- , 2008, https://doi.org/10.2142/biophys.48.S101_4 
49
2P-169 Analysis of Conformation of the pPDM Crosslinked Skeletal Muscle Myosin Using FRET(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S101- , 2008, https://doi.org/10.2142/biophys.48.S101_3 
50
2P-176 Photo-control of ATPase activity of the kinesin motor domains intermolecularly cross-linked by bifunctional photochromic compound(The 46th Annual Meeting of the Biophysical Society of Japan) , Seibutsu Butsuri, 48,  S102- , 2008, https://doi.org/10.2142/biophys.48.S102_3 
51
Conformational dynamics of loops L11 and L12 of kinesin as revealed by spin-labeling EPR , BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 364( 3), 620- 626, Dec. 2007, https://doi.org/10.1016/j.bbrc.2007.10.043 
52
Photocontrol of kinesin ATPase activity using an azobenzene derivative , The Journal of Biochemistry, 142( 6), 691- 698, Dec. 2007, https://doi.org/10.1093/jb/mvm183 
53
2P153 Monitoring the ATPase kinetic pathway of the novel rice kinesin K16 using fluorescent ATP analogue(Molecular motors,Poster Presentations) , Seibutsu Butsuri, 47,  S151- , 2007, https://doi.org/10.2142/biophys.47.S151_2 
54
2P154 Biochemical analysis of the Rice Kinesin 012 using Fluorescent-ATP Analogue(Molecular motors,Poster Presentations) , Seibutsu Butsuri, 47,  S151- , 2007, https://doi.org/10.2142/biophys.47.S151_3 
55
2P150 Conformational Dynamics of Loop L11 in Kinesin on Microtubuie Measured by Site-Directed Spin Labeling Electron Paramagnetic Resonance(Molecular motors,Oral Presentations) , Seibutsu Butsuri, 47,  S150- , 2007, https://doi.org/10.2142/biophys.47.S150_3 
56
1P081 Photo-regulation of industrial enzymes using photo-responsible caged compound(Proteins-protein enigineering,Poster Presentations) , Seibutsu Butsuri, 47,  S43- , 2007, https://doi.org/10.2142/biophys.47.S43_4 
57
1P080 Photo-Control of Calmodulin function using Photochromic Compound(Proteins-functions, methodology, and protein enigineering,Oral Presentations) , Seibutsu Butsuri, 47,  S43- , 2007, https://doi.org/10.2142/biophys.47.S43_3 
58
2P162 Photo-control of kinesin ATPase using photochromic compound(Molecular motors,Oral Presentations) , Seibutsu Butsuri, 47,  S153- , 2007, https://doi.org/10.2142/biophys.47.S153_3 
59
Intermolecular cross-linking of a novel rice Kinesin k16 motor domain with a photoreactive ATP derivative. , Journal of biochemistry, 139( 5), 831- 6, May. 2006,  
60
Conformational change of the loop L5 in rice kinesin motor domain induced by nucleotide binding. , Journal of biochemistry, 139( 5), 857- 64, May. 2006,  
61
Preparation and characterization of a novel rice plant-specific kinesin. , Journal of biochemistry, 139( 4), 645- 54, Apr. 2006,  
62
2P209 Analysis of conformational changes of functional loop L11 of kinesin using Fluorescence Probe and ESR(37. Molecular motor (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S348- , 2006, https://doi.org/10.2142/biophys.46.S348_1 
63
2P216 Nucleotide dependent intermolecular cross-linking of rice kinesin by photo reactive ATP analogue(37. Molecular motor (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S349- , 2006, https://doi.org/10.2142/biophys.46.S349_4 
64
2P218 Characterization of a Novel Rice Kinesin D04 and Its Interaction with Fluorescent ATP analogue(37. Molecular motor (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S350- , 2006, https://doi.org/10.2142/biophys.46.S350_2 
65
2P217 Cross-linking of kinesin using bifunctional photochromic compounds(37. Molecular motor (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S350- , 2006, https://doi.org/10.2142/biophys.46.S350_1 
66
1P134 Photo-switching Calmodulin modified by Photochromic Molecules(4. Protein engineering,Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S180- , 2006, https://doi.org/10.2142/biophys.46.S180_2 
67
2P219 Interaction of a novel rice kinesin O12 with fluorescent ATP analogue(37. Molecular motor (II),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006) , Seibutsu Butsuri, 46( 2), S350- , 2006, https://doi.org/10.2142/biophys.46.S350_3 
68
2P190 A novel structural intermediate of S1 during re-association with actin : time course analyses using prodan fluorescence , Seibutsu Butsuri, 45,  S167- , 2005, https://doi.org/10.2142/biophys.45.S167_2 
69
2P151 Visualization of the ATP hydrolysis intermediate of myosin II by electron cryo-microscopy , Seibutsu Butsuri, 45,  S157- , 2005, https://doi.org/10.2142/biophys.45.S157_3 
70
3P184 Incorporation of photochromic molecule into the microtubule binding site of Kinesin , Seibutsu Butsuri, 45,  S249- , 2005, https://doi.org/10.2142/biophys.45.S249_4 
71
1P171 Analysis of conformational changes on the functional sites of kinesin using fluorescent probe , Seibutsu Butsuri, 45,  S74- , 2005, https://doi.org/10.2142/biophys.45.S74_3 
72
1P172 Effect of incorporated novel photochromic molecule into the Loop 11 of kinesin , Seibutsu Butsuri, 45,  S74- , 2005, https://doi.org/10.2142/biophys.45.S74_4 
73
Incorporation of an azobenzene derivative into the energy transducing site of skeletal muscle myosin results in photo-induced conformational changes. , Journal of biochemistry, 136( 6), 839- 46, Dec. 2004,  
74
3P183 Role of unique loop L5 in the motor domain of kinesin , Seibutsu Butsuri, 44,  S235- , 2004, https://doi.org/10.2142/biophys.44.S235_3 
75
Interaction of Myosin•ADP•Fluorometal Complexes with Fluorescent Probes and Direct Observation Using Quick-Freeze Deep-Etch Electron Microscopy , J Biochem (Tokyo), 136( 1), 57- 64, 2004, https://doi.org/10.1093/jb/mvh095 
76
Role of the unique loop L5 in the motor domain of kinesin , Seibutsu Butsuri, 43,  S137- , 2003, https://doi.org/10.2142/biophys.43.S137_3 
77
Small Angle Neutron Scattering Study of Smooth Muscle Heavy Meromyosoin , Seibutsu Butsuri, 43,  S127- , 2003, https://doi.org/10.2142/biophys.43.S127_2 
78
Biochemical analysis of C.elegans kinesin and comparative study with mouse kinesin , Seibutsu Butsuri, 43,  S137- , 2003, https://doi.org/10.2142/biophys.43.S137_1 
79
Interaction and conformational change of comlexes with motor proteins , Seibutsu Butsuri, 40,  S63- , 2000, https://doi.org/10.2142/biophys.40.S63_4 

 

MISC
No.Title URL, Journal, Vol( Number), From Page- To Page, Publication date 
1
Photo-Control of Kinesin Dimerization and Motor Activity using Photochromic Molecules , BIOPHYSICAL JOURNAL, 110( 3), 462A- 463A, Feb. 2016 
2
Photo-Regulation of Kinesin Intramolecularly Crosslinked by Bifunctional Azobenzne Derivative at the Coiled-Coil Stalk Region , BIOPHYSICAL JOURNAL, 108( 2), 137A- 138A, Jan. 2015 
3
Development of Photo-Controlled Molecular Shuttle Utilizing ATP Driven Motor Kinesin , BIOPHYSICAL JOURNAL, 108( 2), 136A- 137A, Jan. 2015 
4
Photocontrol of mitotic kinesin Eg5 facilitated by thiol-reactive photochromic molecules incorporated into the loop L5 functional loop , The journal of biochemistry, 155( 3), 195- 206, Mar. 2014 
5
Development of Molecular Shuttle Regulated by External Stimulation Utilizing Kinesin ATP Driven Motor , BIOPHYSICAL JOURNAL, 106( 2), 782A- 782A, Jan. 2014 
6
Photocontrol of Mitotic Kinesin Eg5 by Incorporating of Photochromic Molecule into the Functional Loop L5 , BIOPHYSICAL JOURNAL, 106( 2), 781A- 781A, Jan. 2014 
7
Rice kinesin O12 is identical to kinesin OsKCH1 , JOURNAL OF BIOCHEMISTRY, 152( 2), 207- 208, Aug. 2012 
8
Characterization of the Microtubules Modified with Photochromic Molecules , BIOPHYSICAL JOURNAL, 102( 3), 370A- 371A, Jan. 2012 
9
Biochemical Characterization of the Rice Kinesin O12 and N14 Belonging to Kinesin-14 Family , BIOPHYSICAL JOURNAL, 102( 3), 369A- 369A, Jan. 2012 
10
Incorporation of Photochromic Molecule into the Functional Loop L5 of Kinesin for the Purpose of Photo-Regulation , BIOPHYSICAL JOURNAL, 102( 3), 370A- 370A, Jan. 2012 
11
Characterization of Tubulin Derived from Ginkgo Biloba and its Interaction with Rice Plant Kinesin , BIOPHYSICAL JOURNAL, 102( 3), 699A- 699A, Jan. 2012 
12
Synthesis of a novel fluorescent non-nucleotide ATP analogue and its interaction with myosin ATPase , Journal of Biochemistry, 149( 4), 395- 403, Apr. 1, 2011 
13
Conformational Change of alfa-1 helix of Kinesin , BIOPHYSICAL JOURNAL, 100( 3), 146- 146, Feb. 2011 
14
Characterization of the Plant-Specific Rice Kinesins , BIOPHYSICAL JOURNAL, 100( 3), 121- 121, Feb. 2011 
15
Photo-Regulation of Kinesin ATPase Using Microtubules Modified with Photochromic Molecule , BIOPHYSICAL JOURNAL, 100( 3), 449- 450, Feb. 2011 
16
Preparation and Polymerization of Tubulin of Ginkgo Biloba and its Interaction with Rice Plant Kinesin , BIOPHYSICAL JOURNAL, 100( 3), 450- 450, Feb. 2011 
17
Photocontrol of Myosin V ATPase Activity using Calmodulin Modified with Photochromic Compound , BIOPHYSICAL JOURNAL, 100( 3), 487- 487, Feb. 2011 
18
Ca2+ Dependent Dimerization of Kinesin-CaM and Kinesin-M13 Fusion Proteins , BIOPHYSICAL JOURNAL, 100( 3), 122- 122, Feb. 2011 
19
Function Control of Kinesin using Functionality Loop L5 of Kinesin Midified Photochromic Molecule , BIOPHYSICAL JOURNAL, 100( 3), 119- 120, Feb. 2011 
20
Kinesin-Calmodulin fusion protein as a molecular shuttle , Journal of Biochemistry, 147( 2), 213- 223, Feb. 1, 2010 
21
Interaction of photochromic ATP analogue with myosin ATPase , BIOPHYSICAL JOURNAL, ,  487A- 488A, Jan. 2007 
22
Crystal structure of ADP bound motor domain of the rice kinesin K16 reveals a novel conformation , BIOPHYSICAL JOURNAL, ,  497A- 497A, Jan. 2007 
23
Characterization of the rice specific kinesins and interaction with fluorescent ATP analogue , BIOPHYSICAL JOURNAL, ,  499A- 499A, Jan. 2007 
24
Analysis of conformational changes of Loop L11 of kinesin using fluorescence probe and ESR. , BIOPHYSICAL JOURNAL, ,  497A- 498A, Jan. 2007 
25
Photo-control of kinesin modified by photochromic molecules , BIOPHYSICAL JOURNAL, ,  498A- 498A, Jan. 2007 
26
Incorporation of photochromic molecules as photo-switching in the N-terminal domain of Calmodulin , BIOPHYSICAL JOURNAL, ,  593A- 593A, Jan. 2007 
27
2P163 Cross linking of kinesin using bifunctional photochromic compounds results in photo-regulation of ATPase activity(Molecular motors,Poster Presentations) , Seibutsu Butsuri, 47( 0), S153- , 2007 
28
Purification and characterization of the plant specific kinesin , BIOPHYSICAL JOURNAL, 88( 1), 651A- 651A, Jan. 2005 
29
Conformational change of the unique loop L5 of rice kinesin , BIOPHYSICAL JOURNAL, 88( 1), 648A- 648A, Jan. 2005 
30
Expression and biochemical analysis of rice kinesin , PLANT AND CELL PHYSIOLOGY, 46,  S235- S235, 2005 
31
Comparative studies on biochemical analysis of mouse, C. elegans and rice kinesins. , BIOPHYSICAL JOURNAL, 86( 1), 408A- 408A, Jan. 2004 
32
Formation and Characterization of Kinesin・ADP・Fluorometal Complexes , J Biochem (Tokyo), 132( 4), 573- 579, Oct. 1, 2002 
33
Analysis of the Conformational Change of Myosin during ATP Hydrolysis Using Fluorescence Resonance Energy Transfer , Journal of Biochemistry, 132( 3), 471- 482, Sep. 1, 2002 
34
Interaction of a New Fluorescent ATP Analogue with Skeletal Muscle Myosin Subfragment-1. , J Biochem (Tokyo), 131( 6), 905- 911, 2002 
35
Comformational Changes in the Unique Loops Bordering the ATP Binding Cleft of Skeletal Muscle Myosin Mediate Energy Transduction^1 , Journal of Biochemistry, 128( 4), 695- 704, Oct. 1, 2000 
36
Solution Structure of Myosin-ADP-MgFn Ternary Complex by Fluorescent Probes and Small-Angle Synchrotron X-Ray Scattering. , J Biochem (Tokyo), 128( 4), 687- 694, 2000 
37
Analysis of Conformational Changes at the Unique Loop Adjacent to the ATP Binding Site of Smooth Muscle Myosin Using a Fluorescent Probe. , J Biochem (Tokyo), 127( 2), 199- 204, 2000 
38
Conformational Changes at the Highly Reactive Cystein and Lysine Regions of Skeletal Muscle Myosin Induced by Formation of Transition State Analogues , Journal of Biochemistry, 124( 3), 578- 584, Sep. 1, 1998 
39
A Unique Loop Contributing to the Structure of the ATP-Binding Cleft of Skeletal Muscle Myosin Communicates with the Actin-Binding Site , Journal of Biochemistry, 124( 3), 528- 533, Sep. 1, 1998 
40
ADP/Vanadate Mediated Photocleavage of Myosin Light Chain Kinase at the Autoinhibitory Region. , J Biochem (Tokyo), 124( 3), 557- 564, 1998 
41
Isolation and amino acid sequence of a peptide containing an epoxide-reactive residue from the thermolysin-digest of Scytalidium lignicolum acid protease B. , J Biochem (Tokyo), 99( 5), 1537- 1539, 1986 

 

Conference Activities & Talks
No.Title, Conference, Publication date, Promoter, Venue 
1
SMALL GTPASE RAS FUSED WITH M13 PEPTIDE WHICH IS CONTROLLED BY CALMODULIN IONOCHROMICALLY, , Feb. 12, 2024, ,  
2
PHOTOCONTROL OF CHROMATIN REMODELLING COMPLEXES BY PHOTOSWITCHABLE MOLECULES, , Feb. 12, 2024, ,  
3
Ionochromic regulation of small GTPase Ras with Calmodulin, , Feb. 12, 2024, ,  
4
PHOTOCONTROL OF RAS GTPASE ACTIVITY BY INCORPORATING PHOTO- CHROMIC MOLECULES INTO THE REGULATORY FACTOR OF GAP, , Feb. 12, 2024, ,  
5
AGATHISFLAVONE ISOLATED FROM BRAZILIAN FLORA SHOWS INHIBI- TION OF MITOTIC KINESIN EG5, , Feb. 11, 2024, ,  
6
Photoregulation of Small GTPase Ras using Photoresponsive Protein, , Nov. 16, 2023, ,  
7
A Novel Photochromic inhibitor SP-AB-SP exhibits multiple stages of inhibitory activity on mitotic kinesin Eg5, , Nov. 16, 2023, ,  
8
ono-chromic control of G-protein Ras using calmodulin, , Nov. 15, 2023, ,  
9
Photoregulation of Ras GTPase Activity using regulatory Factor GAP modified with azobenzene derivatives, , Nov. 15, 2023, ,  
10
Novel Photochromic inhibitor of mitotic kinesin Eg5 exhibits multiple inhibitory activity states, , Nov. 1, 2023, ,  
11
Controlling the Ras function using ionochromic molecular device Calmodulin, , Nov. 1, 2023, ,  
12
Photocontrol of Small GTPase Ras using Regulatory Factor GAP modified with Photochromic Nano Devices, , Nov. 1, 2023, ,  
13
Photo-control of Mitotic Kinesin Eg5 using Photoresponsive Protein Aureochrome-1 and Dronpa 145N, , Nov. 1, 2023, ,  
14
Biochemical Characterization of C. elegans Kinesin Bmk-1, , Nov. 1, 2023, ,  
15
Inhibitory Molecular Mechanism of Novel Eg5 Inhibitors, , Oct. 1, 2023, ,  
16
Small GTPase RAS Fused with Light Responsive Protein Exhibits Photoreversible Regulation of GTPase Activity, , Feb. 22, 2023, ,  
17
PHOTO-CONTROL OF SMALL GTPASE RAS GTPASE CYCLE USING PHOTOCHROMIC MOLECULE, , Feb. 22, 2023, ,  
18
PHOTO-SWITCHING COMPOUND THAT CONTROL ATPASE AND MOTOR ACTIVITIES OF MITOTIC KINESIN EG5., , Feb. 21, 2023, ,  
19
The control of bionanomachine using calmodulin based ionochromic nanodevice, , Feb. 21, 2023, ,  
20
Biochemical characterization of C. Elegans kinesin BMK-1, , Feb. 12, 2023, ,  
21
A novel Photochromic inhibitor SPSAB showed inhibition of Eg5 ATPase cycle in ADP state, , Nov. 9, 2022, ,  
22
Photocontrol of small GTPase Ras using its regulatory factor GEF modified with photochromic azobenzene derivative, , Sep. 30, 2022, ,  
23
Photo-control Small GTPase Ras using Photochromic Peptide Inhibitor, , Sep. 30, 2022, ,  
24
Photocontrol of chromatin remodelers Snf2 and BRG1 as an ATP driven molecular motor by photoresponsive protein Dronpa, , Sep. 28, 2022, ,  
25
Ras photocontrol by regulatory factor GAP modified with azobenzene derivative, , Sep. 28, 2022, ,  
26
Control of small G-protein Ras using calmodulin-based ionochromic moleculardevice, , Sep. 28, 2022, ,  
27
Photocontrolled Eg5 inhibitor of mitotic kinesin Eg5 composed of azobenzne and spiropyran derivatives, , Feb. 22, 2022, ,  
28
Photocontrol of small GTPase Ras GTPase cycle using photochromic molecule, , Feb. 22, 2022, ,  
29
Photoregulation of small G-protein RAS by the modification at HVR using azobenzene derivatives, , Feb. 22, 2022, ,  
30
Photocontrol of small GTPase Ras using its regulatory factor GEF modified with photochromic azobenzene derivative, , Nov. 27, 2021, ,  
31
Photocontrol of the small G-protein H-Ras GTPase activity using thiol reactive photochromic compounds incorporated into the HVR domain, , Nov. 26, 2021, ,  
32
A novel photochromic Compound inhibits mitotic kinesin Eg5 in three isomerization states, , Nov. 26, 2021, ,  
33
Photo-control of Small GTPase Ras GTPase Cycle Using Peptide Inhibitor Modified with Azobenzene Derivative, , Nov. 3, 2021, ,  
34
Characterization of Mitotic Kinesin Eg5-ADP-Pi Analogues Ternary Complexes which Mimic different Transient States in ATPase Cycle, , Nov. 3, 2021, ,  
35
Photocontrol the HVR domain in the small G-protein Ras GTPase activity using azobenzene derivatives, , Nov. 3, 2021, ,  
36
Photocontrol of chromatin remodelers Snf2 and BRG1 as an ATP driven molecular motor by photoresponsive protein Dronpa, , Nov. 3, 2021, ,  
37
Screening and characterization of novel potent inhibitors of mitotic kinesin Eg5, , Nov. 3, 2021, ,  
38
Analyzing the three states inhibitory activity of SPSAB, , Nov. 3, 2021, ,  
39
Novel photochromic inhibitor of mitotic Kinesin Eg5 which forms three phtoisomerization states, , Mar. 4, 2021, ,  
40
Structural analysis of small G-protein Ras multimer induced by chemical modification of HVR domain with caged compound, 65th Annual meeting of American Biophysical Society, Feb. 25, 2021, ,  
41
Chromatin remodeler CHD1 forms ternary complexes with ADP and Pi analogue which mimic transient states in ATPase cycle, 65th Annual meeting;of;American Biophysical Society, Feb. 25, 2021, ,  
42
Analyzing the three states inhibitory activity of photochromic kinesin Eg5 inhibitor SPSAB, 65th Annual meeting of American Biophysical Society, Feb. 24, 2021, ,  
43
Interaction and inhibitory mechanisms of kolaflavanone, a Garcinia biflavonoid, with kinesin Eg5, 65th Annual meeting of American Biophysical Society, Feb. 22, 2021, ,  
44
Multiple step photo regulation of mitotic kinesin Eg5 using a novel photochromic Inhibitor composed of Spiropyran and azobenzene, 58th Annual meeting of Biophysical Society of Japan, Sep. 18, 2020, ,  
45
Biflavonoids that inhibit ATPase and microtubule-gliding activities of mitotic kinesin Eg5, 58th Annual meeting of Biophysical Society of Japan, Sep. 18, 2020, ,  
46
Formation of small G-protein Ras multimer induced by chemical modification of HVR domain, 58th Annual meeting of Biophysical Society of Japan, Sep. 17, 2020, ,  
47
Formation of chromatin remodeler Chd1-ADP-Pi analogues ternary complexes which mimic transient states in ATPase cycle., 58th Annual meeting of Biophysical Society of Japan, Sep. 16, 2020, ,  
48
Electron microscopic observation of multimer induced by chemical modification of HVR domain in the small G-protein Ras., 93rd Annual meeting of Japanese Biochemical Society, Sep. 15, 2020, ,  
49
Identification of kolaflavanone, a Garcinia biflavonoid, as novel inhibitor of mitotic kinesin Eg5, 93rd Annual meeting of Japanese Biochemical Society, Sep. 15, 2020, ,  
50
Multistep photo-regulation of Eg5 activity using novel photochromic inhibitor, 93rd Annual meeting of Japanese Biochemical Society, Sep. 14, 2020, ,  
51
INHIBITORY MECHANISM OF PHOTOCHROMIC INHIBITOR FOR MITOTIC KINESIN EG5, 64th American Biophysical Society Annual Meeting, Feb. 2020, ,  
52
PHOTO-CONTROL OF RAS FUNCTION USING PEPTIDE INHIBITOR MODI- FIED WITH AZOBENZENE DERIVATIVE, 64th American Biophysical Society Annual Meeting, Feb. 2020, ,  
53
DEVELOPMENT OF NOVEL PHOTOCHROMIC INHIBITORS FOR KINESIN EG5 WHICH FORM MULTIPLE ISOMERIZATION STATES UTILIZING AZOBEN- ZENE AND SPIROPYRAN, 64th American Biophysical Society Annal Meeting, Feb. 2020, ,  
54
PHOTO-CONTROL OF RAS NUCLEOTIDE EXCHANGE REACTION USING PEPTIDE INHIBITOR MODIFIED WITH SPIROPYRAN DERIVATIVE, 64th American Biophysical Society Annual Meeting, Feb. 2020, ,  
55
Development of processed products utilizing rice flour as by-product from the process of sake production using Hachioji-produced rice, 11th University Consortium Hachioji Student Presentation, Dec. 2019, ,  
56
Photo-regulate small GTPase Ras using photochromic peptide inhibitor, 57th Japanese Biophysical Society Annual Meeting, Sep. 2019, ,  
57
Analysis of properties alteration on the rice starch induced by physical and Enzymatic treatment, 92nd Japanese Biochemical Society Annual Meeting, Sep. 2019, ,  
58
Development of novel Photochromic inhibitors for kinesin Eg5 which form multiple isomerization states utilizing azobenzene and spiropyran, 57th Japanese Biophysical Society Annual Meeting, Sep. 2019, ,  
59
Study on inhibitory mechanism of kinesin Eg5 with photochromic Eg5 inhibitor composed of two azobenzene, 57th Japanese Biophysical Society Annual Meeting, Sep. 2019, ,  
60
INHIBITION OF MITOTIC KINESIN EG5 BY KOLAFLAVANONE, 57th Japanese Biophysical Society Annual Meeting, Sep. 2019, ,  
61
Photo-control of Ras nucleotide exchange reaction using the inhibitor peptides modified with spiropyran, 57th Japanese Biophysical Society Annual Meeting, Sep. 2019, ,  
62
PHOTO-CONTROL OF RAS GDP-GTP EXCHANGE USING THE SOSΑH MIMICKING PEPTIDES MODIFIED WITH SPIROPYRAN DERIVATIVE, 63rd Annual Meeting of The Biophysical Society, Mar. 2019, ,  
63
PHOTO-CONTROL OF SMALL GTPASE RAS USING PHOTO RESPONSIVE PEPTIDE INHIBITOR WHICH MIMIC ΑH HELIX OF SOS, 63rd Annual Meeting of The Biophysical Society, Mar. 2019, ,  
64
PHOTO-CONTROL OF SMALL GTPASE RAS GDP-GTP EXCHANGE REACTION USING NOVEL PEPTIDE INHIBITOR MODIFIED WITH AZOBENZENE DERIVATIVES, 63rd Annual Meeting of The Biophysical Society, Mar. 2019, ,  
65
PHOTOCHROMIC INHIBITOR OF MITOTIC KINESIN EG5 COMPOSED OF SPIROPYRAN AND AZOBENZENE DERIVATIVES WHICH EXHIBITS MULTIPLE ISOMERIZATION STATES, 63rd Annual Meeting of The Biophysical Society, Mar. 2019, ,  
66
HIGHLY EFFICIENT PHOTOCONTROL OF MITOTIC KINESIN EG5 FUNCTION USING A NOVEL INHIBITOR COMPOSED OF PHOTOCHROMIC COMPOUND DIMER, 63rd Annual Meeting of The Biophysical Society, Mar. 2019, ,  
67
Morelloflavone as a Novel Inhibitor for Mitotic Kinesin Eg5, 2019 Annual Meeting of The SEITAI-UNDO GROUP, Jan. 2019, ,  
68
Photo-regulation of kinesin Eg5 activity using novel photochromic inhibitors composed of two photochromic molecules, The 92nd Annual Meeting of The Japanese Biochemical Society, Sep. 2018, ,  
69
Photo-control of Small GTPase Ras Using Photochromic Peptide Inhibitors, The 92nd Annual Meeting of The Japanese Biochemical Society, Sep. 2018, ,  
70
HVR domain of small GTPase Ras changes its conformation in GTPase cycle, The 92nd Annual Meeting of The Japanese Biochemical Society, Sep. 2018, ,  
71
Photo-regulation of Small GTPase Ras using Photochromic SOS-Peptide, The 56th Annual Meeting of The Biophysical Society of Japan, Sep. 2018, ,  
72
Photo-regulation of mitotic kinesin Eg5 using a novel photochromic inhibitor composed of two azobenzene, The 56th Annual Meeting of The Biophysical Society of Japan, Sep. 2018, ,  
73
Photo-control of Ras GDP-GTP exchange using the peptide modified with spiropyran derivative, The 56th Annual Meeting of The Biophysical Society of Japan, Sep. 2018, ,  
74
Photoregulation of kinesin Eg5 using photochromic compound composed of azobenzene and spiropyran which forms three isomerization states, The 56th Annual Meeting of The Biophysical Society of Japan, Sep. 2018, ,  
75
Identification of morelloflavone as novel inhibitor of mitotic kinesin Eg5, The Regular Meeting of The Japanese Biochemical Society, Kanto Branch 2018, Jun. 2018, ,  
76
Photo-regulation of Small GTPase Ras Using Peptide Modified with Azobenzene, The Regular Meeting of The Japanese Biochemical Society , Kanto Branch 2018, Jun. 2018, ,  
77
Photo-control of Small GTPase Ras Using Novel Photochromic Peptide Inhibitor, The regular Meeting of The Japanese Biochemical Society, Kanto Branch 2018, Jun. 2018, ,  
78
Photochromic inhibitor of kinesin Eg5 composed of two spiropyran derivatives, The Regular Meeting of The Japanese Biochemical Society, Kanto Branch 2018, Jun. 2018, ,  
79
Photochromic inhibitor of kinesin Eg5 which forms three isomerization states, The Regular Meeting of the Japanese Biochemical Society, Kanto Branch 2018, Jun. 2018, ,  
80
Cross-linking of kinesin using bifunctional photochromic compounds, 44, Nov. 2006, ,  
81
Visualization of the ATP hydrolysis intermediates of myosin II by electron cryo-microscopy, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
82
Interaction of a novl rice kinesin O12 with fluorescent ATP analogue, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
83
Analysis of conformational changes of functional loop L11 of kinesin using fluorescence probe and ESR, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
84
Characterization of a novel rice kinesin D04 and its interaction with fluorescent ATP analogue, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
85
Nucleotide dependent intermolecular cross-lnking of rice kinesin by photo reactive ATP analogue, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
86
Photo-switching calmodulin modified by photochromic molecules, 44th Japanese Biophysical Society Annual Meeting, Nov. 2006, ,  
87
Photo-control of kinesin ATPase activity by photochromic compounds, 79th Japanese Biochemical Society Annual Meeting, Jun. 2006, ,  
88
Characterizations of a rice plant specific kinesin O12, 79th Japanese Biochemical Society Annual Meeting, Jun. 2006, ,  
89
Incorporation of photochromic molecules into calmodulin as photoswitching, 79th Japanese Biochemical Society Annual Meeting, Jun. 2006, ,  
90
Photo-regulation of acto myosin ATPase activity using photochromic molecules, 79th Japanese Biochemical Society Annual Meeting, Jun. 2006, ,  

 

Awards Honors
No.Publication date, Association, Prize, Subtitle 
1
Dec. 2023, , Outstanding performance award, Bionanomachine control by calmodulin based ionochromic bionanodevice 
2
Dec. 2018, The Consortium of Univewrsity in Hachioji, The 10th University Consortium Hachioji Student presentation Jury Award,  
3
2009, Hachioji City, Best Presentation Prize,  

 

Research Grants & Projects
No.Offer organization, System name, Title, Fund classification, Date 
1
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Photoregulation of cellular functions using mitotic kinesin Eg5 inhibitors with photoswitching mechanism, ,  Apr. 2023 - Mar. 2027 
2
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Photo-regulation of mitotic kinesin Eg5 function using photochromic inhibitors which have multiple photo-switching states, ,  Apr. 2019 - Mar. 2024 
3
Hachioji City, , Development of processed products utilizing rice rice flour as a by-product from the process of sake production using Hachioji-produced rice, ,  2019 - 2019 
4
Hachioji Cuty, , Development of processed food using rice flour of sake rice from Hachioji, ,  2019 - 2019 
5
Japan Society for the Promotion of Science, , Development of small GTPase Ras with light switch mechanism and photo control of intracellular signal transduction, ,  2018 - 2018 
6
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of photochromic anti-cancer agent : kinesin Eg5 inhibitor, ,  2011 - 2013 
7
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of photo-driven bionano-machines, competitive_research_funding,  2008 - 2010 
8
Japan Society for the Promotion of Science (JSPS), Grants-in-Aid for Scientific Research, characterization and structural analysis of plant specific kinesin encoded on the rice genome, competitive_research_funding,  2007 - 2010 
9
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Development of photo-driven motor proteins using phtochromic molecules, ,  2002 - 2005 
10
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Analysis of a ADP-bound non-muscle myosin molecule, ,  2002 - 2003 
11
Japan Society for the Promotion of Science, Grants-in-Aid for Scientific Research, Role of the unique loops located in the dotor domain of myosin and kinesin, ,  1999 - 2001 

 

Works
No.Title, Type, Publication date, Venue 
1
Development of processed food representing Hachioji using rice gel derived from Hachioji special rice, ,  May. 2018 - Jan. 2019,  
2
Soka University Open Research Project, ,  2008 - 2010,  
3
Soka University Open Research Project, ,  2008 - 2010,